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Research status of omics technology in the research of prevention and treatment of pulmonary fibrosis with traditional Chinese medicine
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Ni-ni LIAN1, 2, Ya-li LUO1, 2, 3, Lin-feng RUAN1, 2, Jing LUO1, 2, Li FENG1, 2, Xin-ru DENG1, 2
Chinese Journal of Clinical Pharmacology | 2025, 41(4) : 570 - 575
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Chinese Journal of Clinical Pharmacology | 2025, 41(4): 570-575
• Review •
Research status of omics technology in the research of prevention and treatment of pulmonary fibrosis with traditional Chinese medicine
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Ni-ni LIAN1, 2, Ya-li LUO1, 2, 3, Lin-feng RUAN1, 2, Jing LUO1, 2, Li FENG1, 2, Xin-ru DENG1, 2
Affiliations
  • 1.Basic Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Provincial Key Laboratory of Molecular Medicine and TCM for the Prevention and Treatment of Major Diseases in Colleges and Universities of Gansu Province, Lanzhou 730000, Gansu Province, China
  • 3.Key Laboratory of Dunhuang Medicine and Translational of Ministry of Education, Lanzhou 730000, Gansu Province, China
Published: 2025-02-28 doi: 10.13699/j.cnki.1001-6821.2025.04.025
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Pulmonary fibrosis (PF) is a kind of interstitial lung disease with unknown cause. The mechanism of traditional Chinese medicine in the prevention and treatment of PF needs to be strengthened. Traditional Chinese medicine and its compounds can play a therapeutic role in the prevention and treatment of PF from multiple targets and pathways. Because of the complex components of traditional Chinese medicine and single research method, the research process is slow. In recent years, omics technologies (proteomics, metabolomics, transcriptomics, genomics) are helpful to explore and screen clinical biomarkers and new prevention and treatment targets of PF, providing ideas and strategies for the development of targeted traditional Chinese medicine. In this review, we summarize the application of different omics technologies in the research of PF in recent years, and analyze the progress of omics technology in revealing the therapeutic mechanism of traditional Chinese medicine. We also discuss the advantages and limitations of omics technology, and think about the future research direction of PF.

Chinese medicine  /  pulmonary fibrosis  /  omics technology  /  effect mechanism
Ni-ni LIAN, Ya-li LUO, Lin-feng RUAN, Jing LUO, Li FENG, Xin-ru DENG. Research status of omics technology in the research of prevention and treatment of pulmonary fibrosis with traditional Chinese medicine[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (4) : 570 -575 . DOI: 10.13699/j.cnki.1001-6821.2025.04.025
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doi: 10.13699/j.cnki.1001-6821.2025.04.025
  • Receive Date：2024-08-15
  • Online Date：2026-08-04
  • Published：2025-02-28
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  • Received：2024-08-15
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Affiliations
    1.Basic Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Provincial Key Laboratory of Molecular Medicine and TCM for the Prevention and Treatment of Major Diseases in Colleges and Universities of Gansu Province, Lanzhou 730000, Gansu Province, China
    3.Key Laboratory of Dunhuang Medicine and Translational of Ministry of Education, Lanzhou 730000, Gansu Province, China
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表12种不同金属材料的力学参数
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Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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