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Research status of the modulation of TRPV1 signaling pathway and related factors by traditional Chinese medicine for the treatment of herpes zoster and postherpetic neuralgia
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Xiao-tao XIE1, Fan-qi NIU1, Yu-jing PAN1, Shi-ye HE1, Si-nong WANG1, Wen-li ZHOU2
Chinese Journal of Clinical Pharmacology | 2025, 41(3) : 433 - 437
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Chinese Journal of Clinical Pharmacology | 2025, 41(3): 433-437
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Research status of the modulation of TRPV1 signaling pathway and related factors by traditional Chinese medicine for the treatment of herpes zoster and postherpetic neuralgia
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Xiao-tao XIE1, Fan-qi NIU1, Yu-jing PAN1, Shi-ye HE1, Si-nong WANG1, Wen-li ZHOU2
Affiliations
  • 1.School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Dermatology, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Published: 2025-02-17 doi: 10.13699/j.cnki.1001-6821.2025.03.027
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The transient receptor potential vanilloid subtype 1 (TRPV1) signaling pathway is closely related to herpes zoster (HZ) and postherpetic neuralgia (PHN). Traditional Chinese medicine (TCM) has been involved in regulating the TRPV1 signaling pathway in several ways, and has been used to treat HZ and PHN by modulating the aberrant release of TRPV1-associated neuropeptides and inflammatory factors, and neurogenic inflammatory response, etc. This paper summarizes the mechanism and role of TCM in regulating TRPV1 signaling pathway in the treatment of HZ and PHN in recent years, which will provide new ideas for the treatment of HZ and PHN and drug development.

traditional Chinese medicine  /  herpes zoster and postherpetic neuralgia  /  transient receptor potential vanilloid subtype 1  /  inflammatory factor  /  neurogenic inflammation of the skin
Xiao-tao XIE, Fan-qi NIU, Yu-jing PAN, Shi-ye HE, Si-nong WANG, Wen-li ZHOU. Research status of the modulation of TRPV1 signaling pathway and related factors by traditional Chinese medicine for the treatment of herpes zoster and postherpetic neuralgia[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (3) : 433 -437 . DOI: 10.13699/j.cnki.1001-6821.2025.03.027
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.03.027
  • Receive Date：2024-07-29
  • Online Date：2026-08-04
  • Published：2025-02-17
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  • Received：2024-07-29
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Affiliations
    1.School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Department of Dermatology, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
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