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Research progress of the involvement of the cross-talk between endothelial cells and cardiomyocytes in doxorubicin-induced cardiotoxicity
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Li-ping QU1, Zhi-qiang MIN1, Cheng ZHANG1, Xi PENG1, Xiao-shuai LIU2, Wen-jun ZOU1
Chinese Journal of Clinical Pharmacology | 2025, 41(3) : 410 - 415
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Chinese Journal of Clinical Pharmacology | 2025, 41(3): 410-415
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Research progress of the involvement of the cross-talk between endothelial cells and cardiomyocytes in doxorubicin-induced cardiotoxicity
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Li-ping QU1, Zhi-qiang MIN1, Cheng ZHANG1, Xi PENG1, Xiao-shuai LIU2, Wen-jun ZOU1
Affiliations
  • 1.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan Province, China
  • 2.Operations Management Oepartment, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Published: 2025-02-17 doi: 10.13699/j.cnki.1001-6821.2025.03.023
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Doxorubicin is widely used as a first-line therapeutic option in the treatment of several malignant tumors, but its clinical application is severely limited by the dose-dependent and irreversible cardiotoxicity, which has been a long-standing clinical challenge. We analyze the latest clinical guidelines on oncological cardiology and summarize the current status of doxorubicin-induced cardiotoxicity (DIC) prevention and treatment. On this basis, we have gone beyond the traditional view of direct damage to cardiomyocytes, and reviewed the research progress in recent years on the cross-talk between cardiac vascular endothelial cells and cardiomyocytes involved in DIC. The results suggest that cardiac endothelial cells play a key role in the development and maintenance of cardiac function. Doxorubicin not only directly damages these cells, but also disrupts the paracrine signals and physical barriers between them and cardiomyocytes, ultimately leading to an imbalance in cell communication and affecting cardiomyocyte survival and function, resulting in DIC.

doxorubicin-induced cardiotoxicity  /  cardiomyocyte  /  endothelial cell  /  paracrine  /  physical barriers
Li-ping QU, Zhi-qiang MIN, Cheng ZHANG, Xi PENG, Xiao-shuai LIU, Wen-jun ZOU. Research progress of the involvement of the cross-talk between endothelial cells and cardiomyocytes in doxorubicin-induced cardiotoxicity[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (3) : 410 -415 . DOI: 10.13699/j.cnki.1001-6821.2025.03.023
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doi: 10.13699/j.cnki.1001-6821.2025.03.023
  • Receive Date：2024-07-20
  • Online Date：2026-08-04
  • Published：2025-02-17
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  • Received：2024-07-20
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Affiliations
    1.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan Province, China
    2.Operations Management Oepartment, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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