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Outline
Diabetic kidney disease (DKD) is one of the major complications caused by diabetes mellitus, due to its insidious onset, complex pathogenesis and not yet fully defined, it is easy to be delayed for a long period of time to progress to end-stage renal disease (ESRD) or even lead to death. DKD is characterized by the progressive aggravation of urinary protein, and is accompanied by different degrees of glomerulosclerosis, tubular dilatation, interstitial fibrosis and other renal pathologic changes. Data show that hyperglycemic state leads to decreased expression of SIRT1, and SIRT1 has been found to improve renal tissue damage and protect renal function. Therefore, SIRT1 may become a potential target for DKD prevention and treatment, inhibiting renal fibrosis and delaying DKD progression by promoting podocyte autophagy, reducing oxidative stress and inflammatory response. In this paper, we focus on the experimental studies of Chinese medicine extracts targeting the SIRT1 signaling pathway to prevent and control DKD, with a view to providing new ideas and reference basis for the clinical treatment of DKD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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