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Analysis of the effectiveness and acceptability of antidepressants in the treatment of postpartum depression
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Wen-feng LI1, Ke XU2, Xin WEN3, Meng LI1, Hai YUAN1, De-rong KONG1, Wei-feng MI2
Chinese Journal of Clinical Pharmacology | 2025, 41(2) : 245 - 249
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Chinese Journal of Clinical Pharmacology | 2025, 41(2): 245-249
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Analysis of the effectiveness and acceptability of antidepressants in the treatment of postpartum depression
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Wen-feng LI1, Ke XU2, Xin WEN3, Meng LI1, Hai YUAN1, De-rong KONG1, Wei-feng MI2
Affiliations
  • 1.Intensive Psychiatry, Zhengzhou Eighth People’s Hospital, Zhengzhou 450015, Henan Province, China
  • 2.National Institute for Drug Clinical Trial, Peking University Sixth Hospital, Peking University Institute of Mental Health, National Health Commission Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100083, China
  • 3.Peking-Tsinghua Centre for Life Sciences, Peking University, Beijing 100084, China
Published: 2025-01-28 doi: 10.13699/j.cnki.1001-6821.2025.02.019
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Objective

To systematically evaluate the effectiveness and acceptability of antidepressant drugs in the treatment of postpartum depression (PPD).

Methods

The PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Journals of Chinese Scienc were searched, and Chinese Biomedical Literature Service System (SinoMed) database until November 2023. Screen randomized controlled trials (RCTs) of antidepressant drugs for the treatment of PPD. The treatment group was given antidepressant drugs, and the control group was given placebo or another antidepressant drug. Meta-analysis of effectiveness and acceptability is performed using Stata 17.0 software.

Results

A total of 27 RCTs with a total of 2 202 patients were included. The results of meta-analysis showed: The top three efficacy relative to placebo were mirtazapine [odds ratio (OR) = 2.25, 95% confidence interval (CI) = (1.20-3.30), P<0.05], nortriptyline [OR=1.50, 95%CI=(0.55-2.44), P>0.05], venlafaxine [OR=1.35, 95% CI=(0.13-2.56), P>0.05]. Acceptability is compared with placebo in the top three Chinese herbal medicine [OR=0.47, 95% CI=(-0.72-1.66), P>0.05], nortriptyline [OR=-0.08, 95% CI=(-1.16-1.33), P>0.05], venlafaxine [OR=-0.12, 95% CI=(-1.47-1.24), P>0.05].

Conclusion

Nortriptyline, venlafaxine, trazodone, and duloxetine are effective in treating PPD without obvious adverse drug reactions.

antidepressants  /  postpartum depression  /  effectiveness  /  acceptability  /  network meta-analysis
Wen-feng LI, Ke XU, Xin WEN, Meng LI, Hai YUAN, De-rong KONG, Wei-feng MI. Analysis of the effectiveness and acceptability of antidepressants in the treatment of postpartum depression[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (2) : 245 -249 . DOI: 10.13699/j.cnki.1001-6821.2025.02.019
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.02.019
  • Receive Date：2024-07-25
  • Online Date：2026-08-04
  • Published：2025-01-28
Article Data
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History
  • Received：2024-07-25
Affiliations
    1.Intensive Psychiatry, Zhengzhou Eighth People’s Hospital, Zhengzhou 450015, Henan Province, China
    2.National Institute for Drug Clinical Trial, Peking University Sixth Hospital, Peking University Institute of Mental Health, National Health Commission Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100083, China
    3.Peking-Tsinghua Centre for Life Sciences, Peking University, Beijing 100084, China
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