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Research status of insulin resistance mechanisms and the improvement of insulin resistance by active ingredients of dark plum
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Zhen-ni ZHANG1, Wen-fang JIN1, Hu-gang JIANG1, 2, Xin-qiang WANG1, 2, Kai LIU1, 2, Ying-dong LI1, 2, Xin-ke ZHAO1, 2
Chinese Journal of Clinical Pharmacology | 2025, 41(2) : 274 - 278
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Chinese Journal of Clinical Pharmacology | 2025, 41(2): 274-278
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Research status of insulin resistance mechanisms and the improvement of insulin resistance by active ingredients of dark plum
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Zhen-ni ZHANG1, Wen-fang JIN1, Hu-gang JIANG1, 2, Xin-qiang WANG1, 2, Kai LIU1, 2, Ying-dong LI1, 2, Xin-ke ZHAO1, 2
Affiliations
  • 1.School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Cardiology, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
Published: 2025-01-28 doi: 10.13699/j.cnki.1001-6821.2025.02.025
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Dark plum can be used to treat symptoms such as consumptive thirst due to deficiency-heat and chronic cough due to lung deficiency. Its active ingredients have auxiliary effects on lowering blood glucose, antibacterial and anti-inflammatory activities. Insulin resistance is mainly characterized by the weakening of the physiological effects of insulin in the body, with a relatively complex mechanism that can lead to various metabolic-related diseases and seriously affect health. The active ingredients of dark plum can improve insulin resistance by regulating insulin signaling pathways, endoplasmic reticulum stress, antioxidant stress, inflammatory signaling pathways, levels of related inflammatory mediators, and free fatty acid levels. By reviewing the relevant literature on the improvement of insulin resistance by the active ingredients of dark plum, this article summarizes and analyzes its mechanism of action, aiming to provide new ideas and scientific evidence for in-depth research on insulin resistance and the development and application of drugs.

dark plum  /  active ingredient  /  signaling pathway  /  stress response  /  insulin resistance
Zhen-ni ZHANG, Wen-fang JIN, Hu-gang JIANG, Xin-qiang WANG, Kai LIU, Ying-dong LI, Xin-ke ZHAO. Research status of insulin resistance mechanisms and the improvement of insulin resistance by active ingredients of dark plum[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (2) : 274 -278 . DOI: 10.13699/j.cnki.1001-6821.2025.02.025
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doi: 10.13699/j.cnki.1001-6821.2025.02.025
  • Receive Date：2024-07-20
  • Online Date：2026-08-04
  • Published：2025-01-28
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  • Received：2024-07-20
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Affiliations
    1.School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Department of Cardiology, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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