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Status in the application of Saccharomyces boulardii versus in the treatment of pediatric diarrhea
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Li-li MOU1a, Jian-zhao CHEN1a, Mei ZHUANG1a, Jin-lian XUE1b, Lan-lan CHEN1b, Ying YANG1b, Yong LIU1c, Mei-xing YAN2
Chinese Journal of Clinical Pharmacology | 2025, 41(3) : 428 - 432
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Chinese Journal of Clinical Pharmacology | 2025, 41(3): 428-432
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Status in the application of Saccharomyces boulardii versus in the treatment of pediatric diarrhea
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Li-li MOU1a, Jian-zhao CHEN1a, Mei ZHUANG1a, Jin-lian XUE1b, Lan-lan CHEN1b, Ying YANG1b, Yong LIU1c, Mei-xing YAN2
Affiliations
  • 1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China
  • 1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China
  • 1c.Department of Otolaryngology, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China
  • 2.Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China
Published: 2025-02-17 doi: 10.13699/j.cnki.1001-6821.2025.03.026
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Saccharomyces boulardii (S. boulardii), as the sole fungal probiotic, exhibits significant therapeutic efficacy in treating various gastrointestinal disorders. In contrast to traditional bacterial probiotic preparations, S. boulardii stands out for its diverse array of biological activities, including anti-inflammatory, antibacterial, enzymatic, metabolic, and anti-toxin properties. S. boulardii is not indigenous to the human microbiome and is resistant to gastric acid, ensuring its stability and tolerability. Clinical research indicates that S. boulardii offers a positive therapeutic effect in treating gastrointestinal disorders such as acute diarrhea, antibiotic-induced diarrhea, inflammatory bowel disease, and irritable bowel syndrome, while also demonstrating high oral safety. Although the specific mechanisms of action of S. boulardii remain unclear, its clinical efficacy has been widely recognized. This article provides an overview of the advancements in S. boulardii’s application in treating childhood gastrointestinal diseases, serving as a reference for future research directions and clinical applications of this fungus.

Saccharomyces boulardii  /  pediatric diarrhea  /  gastrointestinal disease  /  clinical research
Li-li MOU, Jian-zhao CHEN, Mei ZHUANG, Jin-lian XUE, Lan-lan CHEN, Ying YANG, Yong LIU, Mei-xing YAN. Status in the application of Saccharomyces boulardii versus in the treatment of pediatric diarrhea[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (3) : 428 -432 . DOI: 10.13699/j.cnki.1001-6821.2025.03.026
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doi: 10.13699/j.cnki.1001-6821.2025.03.026
  • Receive Date：2024-08-07
  • Online Date：2026-08-04
  • Published：2025-02-17
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  • Received：2024-08-07
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Affiliations
    1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China
    1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China
    1c.Department of Otolaryngology, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China
    2.Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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