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Research status of p38 mitogen-activated protein kinases signaling pathway in osteosarcoma
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Qing-qing QIN1, Yi-kun WANG1, Qing-lin YANG1, Yong-ping WANG1, 2
Chinese Journal of Clinical Pharmacology | 2025, 41(1) : 105 - 110
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Chinese Journal of Clinical Pharmacology | 2025, 41(1): 105-110
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Research status of p38 mitogen-activated protein kinases signaling pathway in osteosarcoma
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Qing-qing QIN1, Yi-kun WANG1, Qing-lin YANG1, Yong-ping WANG1, 2
Affiliations
  • 1.The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China
  • 2.Department of Orthopedics, The Second Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
Published: 2025-01-17 doi: 10.13699/j.cnki.1001-6821.2025.01.022
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p38 mitogen-activated protein kinases (p38 MAPK) are involved in the regulation of osteosarcoma (OS) development. Therefore, this paper reviews the current research status of p38 MAPK signaling pathway in OS, mainly including the p38 MAPK signaling pathway regulates the biological behaviors of OS such as proliferation, migration, invasion, apoptosis, autophagy, iron death, angiogenesis and epithelial-mesenchymal transition (EMT), and non-coding RNAs and oxidative stress are involved in the development of OS through the modulation of p38 MAPK signaling pathway. reviewed to provide new ideas for finding the treatment of OS.

p38 mitogen-activated protein kinases  /  osteosarcoma  /  signaling pathway
Qing-qing QIN, Yi-kun WANG, Qing-lin YANG, Yong-ping WANG. Research status of p38 mitogen-activated protein kinases signaling pathway in osteosarcoma[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (1) : 105 -110 . DOI: 10.13699/j.cnki.1001-6821.2025.01.022
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doi: 10.13699/j.cnki.1001-6821.2025.01.022
  • Receive Date：2024-09-26
  • Online Date：2026-08-04
  • Published：2025-01-17
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  • Received：2024-09-26
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Affiliations
    1.The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China
    2.Department of Orthopedics, The Second Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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