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Sacubitril valsartan sodium tablets are a novel supramolecular co-crystal drug that combines the dual effects of angiotensin receptor blockade and neprilysin inhibitor. It has shown broad application prospects in heart failure, hypertension, maintaining water sodium balance in the body, and protecting target organs, etc. It is a major breakthrough in cardiovascular treatment drugs in recent years. It is clinically used in China for chronic heart failure in adult patients with reduced ejection fraction and primary hypertension. In recent years, pharmaceutical co-crystals has become a hot topic in the research of crystalline drugs, and sacubitril valsartan sodium tablets, as a marketed co-crystal drug, have attracted industry attention. This article summarizes the characteristics of sacubitril valsartan sodium co-crystal drug, the application and approval cases through relevant literature investigation, and discussses pharmaceutical research of the formulation, in order to provide some references for the research and development of generic drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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