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The glycocalyx (GC) constitutes an essential component of the vascular endothelial cell surface, facilitating vasodilation, regulating vascular permeability, modulating leukocyte adhesion, and exerting anti-inflammatory effects. Under the influence of diverse pathological factors, GC degradation is triggered, and endothelial cell dysfunction is mediated through various mechanisms such as oxidative stress, exacerbated inflammatory responses, abnormal mechanical transduction, and augmented white blood cell adhesion. Furthermore, dysfunctional endothelial cells can also lead to an intensification of GC degradation. In this paper, the potential correlation between GC degradation and endothelial cell dysfunction, along with related drug intervention studies, were summarized and analyzed, which provided ideas for subsequent drug research and pave the way for improving clinical efficacy of related diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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