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Pulmonary arterial hypertension treatment drugs——WINREVAIR
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Yu-shan NING1a, Tao-hua SUN1b, An-jin CHEN1b, Rong WEI1c
Chinese Journal of Clinical Pharmacology | 2025, 41(1) : 96 - 99
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Chinese Journal of Clinical Pharmacology | 2025, 41(1): 96-99
• New Drugs Introduction •
Pulmonary arterial hypertension treatment drugs——WINREVAIR
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Yu-shan NING1a, Tao-hua SUN1b, An-jin CHEN1b, Rong WEI1c
Affiliations
  • 1a.Medical Journal Editorial Department, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
  • 1b.Drug Clinical Trial Research Department, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
  • 1c.Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
Published: 2025-01-17 doi: 10.13699/j.cnki.1001-6821.2025.01.020
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The active ingredient of WINREVAIR, sotatercept-csrk, is a recombinant activin receptor IIA-Fc (ActRIIA-Fc) fusion protein that improves pro-proliferation (ActRIIA/Smad2/3-mediated) and anti-proliferation (BMPRII/Smad1/5/8-mediated) signals, thereby regulating vascular proliferation. In March 2024, WINREVAIR was approved by the U.S. Food and Drug Administration for the treatment of pulmonary arterial hypertension (PAH) in adults. Clinical studies have shown that WINREVAIR can improve exercise capacity and reduce the incidence of all-cause death or clinical worsening of PAH by 84%. Common adverse drugreactions include headache, epistaxis, rash, etc.

WINREVAIR  /  sotatercept-csrk  /  recombinant activin receptor  /  fusion protein  /  pulmonary arterial hypertension
Yu-shan NING, Tao-hua SUN, An-jin CHEN, Rong WEI. Pulmonary arterial hypertension treatment drugs——WINREVAIR[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (1) : 96 -99 . DOI: 10.13699/j.cnki.1001-6821.2025.01.020
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doi: 10.13699/j.cnki.1001-6821.2025.01.020
  • Receive Date：2024-05-07
  • Online Date：2026-08-04
  • Published：2025-01-17
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  • Received：2024-05-07
Funding
Affiliations
    1a.Medical Journal Editorial Department, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
    1b.Drug Clinical Trial Research Department, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
    1c.Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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