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Drug-induced liver injury (DILI) is a common adverse drug reactions in clinical practice, with complex pathophysiological process, the pathogenesis has not been fully elucidated, and lack of objective and specific diagnostic methods and treatment, so the prevention and treatment of DILI has attracted extensive attention from scholars. In recent years, the intestinal flora has become a research hotspot in the field of DILI, and the intestinal flora causes or exacerbates DILI by damaging the intestinal mucosal barrier, affecting the metabolites of the intestinal flora and mediating the immune response, and the gut-liver axis is an important pathway for the intestinal flora to participate in the occurrence of DILI, regulating intestinal flora is practicable in the treatment of DILI. This article reviews the characteristics of intestinal flora in DILI patients, and to explore the possible mechanisms of intestinal flora participating in the pathogenesis of DILI through the gut-liver axis, summarizes the latest progress of intervention in the treatment of DILI by intestinal flora, in order to provide references for the screening of the diagnostic targets of DILI and its prevention and treatment from the perspective of intestinal flora.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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