Home Journals Articles Updates About
CN
image
收藏切换
Research status on the therapeutic potential of paeoniflorin in renal fibrosis based on the PI3K/Akt/mTOR signaling pathway
收藏切换
PDF
Lin-zhen JIA1a, Tian-tian HAN1a, Li-bo WEN1b, 2, Kun ZHAO1b, 2, Ren-jun GAO3, Ying LÜ1b, Xue LI1b, 2
Chinese Journal of Clinical Pharmacology | 2025, 41(1) : 132 - 136
Less
收藏切换
Chinese Journal of Clinical Pharmacology | 2025, 41(1): 132-136
• Review •
Research status on the therapeutic potential of paeoniflorin in renal fibrosis based on the PI3K/Akt/mTOR signaling pathway
Full
Lin-zhen JIA1a, Tian-tian HAN1a, Li-bo WEN1b, 2, Kun ZHAO1b, 2, Ren-jun GAO3, Ying LÜ1b, Xue LI1b, 2
Affiliations
  • 1a.College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, Heilongjiang Province, China
  • 1b.College of Basic Medicine, Qiqihar Medical University, Qiqihar 161006, Heilongjiang Province, China
  • 2.Heilongjiang Provincial Key Laboratory of Medicine-Food Homologous Resources and Metabolic Disease Prevention and Control, Qiqihar 161006, Heilongjiang Province, China
  • 3.The Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, Heilongjiang Province, China
Published: 2025-01-17 doi: 10.13699/j.cnki.1001-6821.2025.01.027
Outline
收藏切换

The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway plays a crucial role in the regulation of renal fibrosis by participating in inflammatory response, oxidative stress and autophagy. Paeoniflorin exhibits remarkable efficacy in treating myocardial and liver fibrosis. This article provides a comprehensive review on the research progress of paeoniflora in preventing and treating renal fibrosis through modulation of the PI3K/Akt/mTOR signaling pathway, offering novel insights for traditional Chinese medicine-based approaches to prevent and treat renal fibrosis.

paeoniflorin  /  traditional Chinese medicine  /  renal fibrosis  /  phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway
Lin-zhen JIA, Tian-tian HAN, Li-bo WEN, Kun ZHAO, Ren-jun GAO, Ying LÜ, Xue LI. Research status on the therapeutic potential of paeoniflorin in renal fibrosis based on the PI3K/Akt/mTOR signaling pathway[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (1) : 132 -136 . DOI: 10.13699/j.cnki.1001-6821.2025.01.027
Appendix
Less
Year 2025 volume 41 Issue 1
PDF
0
0
Cite this Article
BibTeX
Article Info
doi: 10.13699/j.cnki.1001-6821.2025.01.027
  • Receive Date：2024-06-10
  • Online Date：2026-08-04
  • Published：2025-01-17
Article Data
Affiliations
History
  • Received：2024-06-10
Funding
Affiliations
    1a.College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, Heilongjiang Province, China
    1b.College of Basic Medicine, Qiqihar Medical University, Qiqihar 161006, Heilongjiang Province, China
    2.Heilongjiang Provincial Key Laboratory of Medicine-Food Homologous Resources and Metabolic Disease Prevention and Control, Qiqihar 161006, Heilongjiang Province, China
    3.The Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, Heilongjiang Province, China
References
Share
https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.01.027
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House