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Diabetic kidney disease (DKD) is a clinical syndrome in which diabetes leads to microvascular lesions and then glomerulosclerosis. In the progression of DKD, the hypoxia inducible factor-1α (HIF-1α) signaling pathway is involved in the occurrence, development and pathological formation of DKD. Related studies have shown that the HIF-1α pathway is the most critical pathway for the treatment of DKD with traditional Chinese medicine. Among them, Chinese medicine monomers, Chinese medicine compounds, and Chinese patent medicines play a role in preventing interstitial fibrosis and glomerulosclerosis by regulating the HIF-1α pathway. Its mechanism is closely related to inflammation, oxidative stress, cell apoptosis, and ferroptosis. This article reviews the existing research results on the treatment of DKD with the intervention of traditional Chinese medicine in the HIF-1α pathway in recent years, in order to provide a theoretical basis for the prevention and treatment of DKD and the development of new drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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