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Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary neurological injury that occurs after blood flow is restored in patients with ischemic stroke, and its pathological process involves inflammatory cascade imbalance, mitochondrial energy metabolism disorders, calcium ion overload and oxidative stress, which significantly affects the recovery of postoperative neurological function. In recent years, studies have shown that a variety of commonly used anesthetic drugs such as sevoflurane, propofol and dexmedetomidine can exert neuroprotective effects in the perioperative period through multi-target and pathway-specific mechanisms, thereby effectively alleviating CIRI. This paper summarizes the pathway and clinical application evidence of anesthetic drugs on neuroinflammation, energy metabolism, cell death and other pathways to alleviate CIRI, aiming to provide theoretical basis and research ideas for the optimization of clinical anesthesia regimens and the formulation of neuroprotective regimens.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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