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Ankylosing spondylitis (AS) is an inflammatory autoimmune disease characterised primarily by chronic lower back pain. Its aetiology is complex, with a tendency to run in families, and is associated with factors such as genetics, the immune system and microbial infections. As a vital digestive and immune organ, the gut harbours a diverse microbial community; an imbalance in this microbiota may contribute to the development of AS via the "gut-joint axis". Consequently, this paper elucidates the fundamental principles of the "gut-joint axis" and its relationship with the onset and progression of AS. It summarises the latest research findings on the use of traditional chinese medicine to treat AS by regulating the gut microbiome, optimising microbial metabolism, improving intestinal permeability, and activating the intestinal mucosal immune system. The aim is to provide a reference for further research into the treatment of AS using traditional chinese medicine via the "gut-joint axis".
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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