To explore the efficacy of eravacycline combined with colistimethate sodium in treating sepsis caused by carbapenem-resistant Escherichia coli producing New Delhi metallo-β-lactamase (NDM) secondary to complex intra-abdominal infection.
The anti-infection regimen was dynamically adjusted according to abdominal-pelvic enhanced MRI, laboratory tests, changes in main inflammatory indicators (peripheral blood white blood cell count and procalcitonin), and drug sensitivity test results.
After 13 days of treatment with eravacycline (50 mg, q12h) and colistimethate sodium (150 mg, q12h), the patient's condition and inflammatory indicators improved significantly, with no drug-related adverse reactions during hospitalization.
The combination is safe and effective for the above-mentioned sepsis, providing crucial technical support for clinical treatment of NDM-producing carbapenem-resistant Escherichia coli infections.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |