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Research status on the antitumor potential and mechanism of action of α-Solanine
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Yan-ping YIN1, Song SUN2, Shuo LIU2, Shou-lin SUN3
Chinese Journal of Clinical Pharmacology | 2026, 42(6) : 865 - 872
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Chinese Journal of Clinical Pharmacology | 2026, 42(6): 865-872
• Review •
Research status on the antitumor potential and mechanism of action of α-Solanine
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Yan-ping YIN1, Song SUN2, Shuo LIU2, Shou-lin SUN3
Affiliations
  • 1.Jinan City Tianqiao District Center for Disease Control and Prevention, Jinan 250000, Shandong Province, China
  • 2.Qilu Hospital of Shandong University, Jinan 250000, Shandong Province, China
  • 3.Shandong Provincial Third People’s Hospital, Jinan 250000, Shandong Province, China
Published: 2026-03-28 doi: 10.13699/j.cnki.1001-6821.2026.06.018
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Cancer is one of the major global health burdens, with its incidence and mortality rates continuing to rise. In exploring cancer prevention and treatment strategies, natural products derived from plants have shown great potential. Over long-term evolution, plants have produced a rich array of bioactive compounds, some of which have been successfully developed into anticancer drugs, such as vinca alkaloids. This article focuses on glycosidic alkaloids contained in Solanaceae plants, α-Solanine. Due to its chemical structure similarity to human steroid hormones, this substance is believed to possess various biological activities, including anti-inflammatory and antimicrobial effects. Recent studies have further revealed that α-Solanine exhibits significant antitumor activity in both in vitro and in vivo experiments, capable of inhibiting the proliferation of multiple types of cancer cells. Therefore, this review systematically summarizes the latest advances in α-Solanine’s anticancer properties and highlights its development prospects as a potential anticancer therapeutic agent.

α-Solanine  /  natural compound  /  anti-tumor effect  /  potential anti-cancer drug
Yan-ping YIN, Song SUN, Shuo LIU, Shou-lin SUN. Research status on the antitumor potential and mechanism of action of α-Solanine[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (6) : 865 -872 . DOI: 10.13699/j.cnki.1001-6821.2026.06.018
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Year 2026 volume 42 Issue 6
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Article Info
doi: 10.13699/j.cnki.1001-6821.2026.06.018
  • Receive Date：2026-03-30
  • Online Date：2026-08-06
  • Published：2026-03-28
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  • Received：2026-03-30
Affiliations
    1.Jinan City Tianqiao District Center for Disease Control and Prevention, Jinan 250000, Shandong Province, China
    2.Qilu Hospital of Shandong University, Jinan 250000, Shandong Province, China
    3.Shandong Provincial Third People’s Hospital, Jinan 250000, Shandong Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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