To explore and analyze the efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism, its impact on thyroid function.

Patients with hyperthyroidism were collected and assigned into treatment group and control group. The control group was treated with iodine-131 alone; the treatment group was treated with a combination of propranolol and iodine-131. The efficacy, anxiety (self-rating anxiety scale, SAS) scores and depression (self-rating depression scale, SDS) scores, thyroid hormone levels, cardiac function indicators, and adverse reactions were compared between the two groups.

A total of 160 patients were enrolled, with 80 cases in each group. There was no significant difference in efficacy between the treatment group and the control group (P>0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). After treatment, the SAS score, SDS score, free triiodothyronine (FT3) level, free thyroxine (FT4) level, left ventricular ejection fraction (LVEF) level, stroke volume (SV) level, heart rate level in both groups decreased, and the treatment group was lower than the control group (all P<0.05); the TSH level increased, and the treatment group was higher than the control group (P<0.05).

Compared with the use of iodine-131 alone, the combined treatment of propranolol and iodine-131 for hyperthyroidism can effectively improve thyroid function and cardiac function, and reduce anxiety and depression in patients.