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Bone and joint diseases encompass conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and gouty arthritis. With high prevalence rates and a significant burden of disability, they have become a major global public health issue. Current treatment approaches primarily rely on drug interventions and surgical procedures, with relatively limited options for comprehensive intervention strategies. Psoralea corylifolia L. (Buguzhi), a traditional Chinese medicinal herb, is rich in various flavonoid small-molecule compounds. Its multi-targeted, multi-step regulatory advantages have drawn significant attention in the prevention and treatment of bone and joint diseases. Existing evidence indicates that these compounds exhibit comprehensive effects including osteogenesis promotion, osteoclast inhibition, anti-inflammation, antioxidant activity, and metabolic regulation, However, its key active substances and functional networks have yet to be systematically elucidated. Based on this, this paper aims to systematically elucidate the pharmacological actions and molecular mechanisms of psoralen flavonoids in the treatment of osteoarthritis, with the goal of providing novel research perspectives and potential strategies for the clinical prevention and treatment of this condition. Furthermore, it explores the prospects for clinical translation and the primary challenges encountered.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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