PDF
Full
Outline
Brexpiprazole, a novel atypical antipsychotic drug, has therapeutic effects in the treatment and prevention of relapse of schizophrenia. It exerts its efficacy through partial agonism of dopamine D2 receptor and 5-hydroxytryptamine receptor 1A (5-HT1A), as well as antagonism of 5-HT2A receptor. In terms of pharmacokinetics, it features high oral bioavailability, a long half-life, and minimal influence of food on its absorption. Multiple clinical trials have confirmed its effectiveness in the acute treatment (2-4mg every day) and maintenance treatment (1-4mg every day) of schizophrenia. Regarding safety, common adverse reactions include akathisia and weight gain, with a relatively low risk of metabolic abnormalities. No systematic review of brexpiprazole has been published in China. This article conducts a systematic search for the first time and reviews it from aspects such as its mechanism of action, pharmacokinetic characteristics, clinical efficacy, and safety, providing a reference for rational clinical use.
PDF
185
36
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
