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Narsoplimab was first approved by the U.S. Food and Drug Administration (FDA) on December 24,2025, for the management of thrombotic microangiopathy following hematopoietic stem cell transplantation (TA-TMA) in children aged 2 years and older and adults. As a serious complication of hematopoietic stem cell transplantation (HSCT), TA-TMA is characterized by high mortality. TA-TMA is associated with endothelial injury and can activate the complement agglutinin pathway, where mannose-binding agglutinin-related serine protease-2 (MASP-2) is a key enzyme. Narsoplimab is a humanized monoclonal antibody that specifically binds to and inhibits MASP-2, thereby reducing complement activation in damaged tissues without compromising the beneficial role of complement in anti-infection. Multiple real-world studies have demonstrated a high response rate. This article provides an overview of the mechanism of action, pharmacodynamics, pharmacokinetics, clinical studies, and safety profile of Narsoplimab.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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