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To analyze the steady state plasma concentrations and dose-corrected concentration(C/D) influencing factors of vortioxetine tablets in patients with depression, and to provide guidance in the practice of rational clinical use of vortioxetine tablets in patients with depression.
Patients with depression who took vortioxetine and underwent therapeutic drug monitoring of blood concentrations in our hospital from March 2022 to November 2024 were selected as the study subjects, and their blood concentrations were monitored. Laboratory indicators, demographic information and the effect of coadministration on dose-corrected concentrations of vortioxetine tablets were statistically analyzed by SPSS 26.0.
A total of 90 patients were enrolled, and 107 sessions of blood concentration monitoring were performed. In depressed patients, the steady state plasma concentration was (28.05±20.28) ng·mL-1, the administered daily dose was (14.86 ± 5.21) mg·d-1, and the dose-corrected concentration was (1.96±1.24) ng·mL-1·mg-1·d. 69.16% (74 cases/107 cases) of C/D exceeded the upper limit of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie(AGNP) guideline reference range. The body weight, alanine aminotransferase(ALT), and urea, as well as the combination of paliperidone, aripiprazole, or clozapine all had a significant effect on the dose-corrected concentration of vortioxetine (all P<0.05). Multiple linear regression analysis revealed that body weight and the combination of aripiprazole had a significant effect on vortioxetine C/D (F=8.517, R2=0.148, P<0.001).
When vortioxetine is used clinically, the dosage should be adjusted according to the patient’s body weight. When it is used in conjunction with aripiprazole, regular monitoring of the plasma concentration should be carried out.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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