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Ischemic stroke, characterized by reduced cerebral blood flow leading to neurological dysfunction, has high mortality and disability rates. Traditional Chinese medicine (TCM) not only alleviates symptoms but also reduces complications, making it widely used clinically. However, due to the multi-component, multi-target and multi-pathway nature of TCM, the mechanisms of many drugs remain unclear. Network pharmacology and metabolomics, as branches of systems biology, have become hotspots in TCM research. Network pharmacology reveals drug mechanisms through target network analysis, while metabolomics assesses metabolic pathway alterations. This review analyzes recent literature from three aspects, including single herbs, herb pairs and compound prescriptions, summarizing advances in network pharmacology and metabolomics research on TCM for ischemic stroke, providing a systematic theoretical basis for clinical application.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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