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Research status of the correlation between hyperuricemia and cardiovascular diseases
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Xiu-zhen DI1, Xiao-hui WANG1, Hua SUN1, Nan BAI2
Chinese Journal of Clinical Pharmacology | 2025, 41(23) : 3399 - 3407
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Chinese Journal of Clinical Pharmacology | 2025, 41(23): 3399-3407
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Research status of the correlation between hyperuricemia and cardiovascular diseases
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Xiu-zhen DI1, Xiao-hui WANG1, Hua SUN1, Nan BAI2
Affiliations
  • 1.Jingnan Medical District, General Hospital of Chinese People’s Liberation Army, Beijing 100841, China
  • 2.The Office of the Medical Ethics Committee, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Published: 2025-12-17 doi: 10.13699/j.cnki.1001-6821.2025.23.014
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Hyperuricemia (HUA) is a metabolic disorder characterized by abnormally elevated serum uric acid levels, with a rising prevalence worldwide. The potential hazards of HUA and its precise intervention strategies have emerged as a central focus in clinical medicine research. Current research indicates that HUA is closely associated with various systemic diseases, such as cardiovascular and renal diseases. Its pathogenic mechanisms involve multiple pathways, such as oxidative stress, inflammatory factor activation, and urate crystal deposition. However, the treatment of HUA patients with comorbid cardiovascular or renal diseases—particularly those with asymptomatic hyperuricemia (AH)—remains highly controversial. Existing clinical guidelines show significant regional variations, European and American guidelines favor a conservative monitoring approach, while Asian guidelines advocate for earlier intervention. Therefore, to establish the long-term clinical benefits for HUA patients, there is an urgent need for evidence-based medical support through large-scale prospective cohort studies and randomized controlled trials (RCTs). These studies will provide a more reliable foundation for standardized clinical management.

hyperuricemia  /  asymptomatic hyperuricemia  /  cardiovascular disease  /  pathogenesis  /  treatment
Xiu-zhen DI, Xiao-hui WANG, Hua SUN, Nan BAI. Research status of the correlation between hyperuricemia and cardiovascular diseases[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (23) : 3399 -3407 . DOI: 10.13699/j.cnki.1001-6821.2025.23.014
Year 2025 volume 41 Issue 23
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doi: 10.13699/j.cnki.1001-6821.2025.23.014
  • Receive Date:2025-09-01
  • Online Date:2026-08-05
  • Published:2025-12-17
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  • Received:2025-09-01
Affiliations
    1.Jingnan Medical District, General Hospital of Chinese People’s Liberation Army, Beijing 100841, China
    2.The Office of the Medical Ethics Committee, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
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种数
Number of
species
占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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