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Pathological mechanism and new progress in drug treatment of metabolic dysfunction-associated steatotic liver disease
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Xin-yue WANG1, Yan-xi LI1, Yan ZHANG2
Chinese Journal of Clinical Pharmacology | 2025, 41(23) : 3382 - 3390
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Chinese Journal of Clinical Pharmacology | 2025, 41(23): 3382-3390
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Pathological mechanism and new progress in drug treatment of metabolic dysfunction-associated steatotic liver disease
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Xin-yue WANG1, Yan-xi LI1, Yan ZHANG2
Affiliations
  • 1.The First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
  • 2.Department of Pharmacology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Published: 2025-12-17 doi: 10.13699/j.cnki.1001-6821.2025.23.012
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The global prevalence and incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) are steadily increasing, with the situation being particularly pronounced in China. Currently, MASLD has become the most common form of chronic liver disease in the country, posing a serious threat to public health. The pathogenesis of MASLD is highly complex, involving multiple contributing factors, which presents significant challenges for researchers exploring treatment strategies. This article provides a comprehensive review of MASLD, with a focus on elucidating its pathogenesis and current advances in therapeutic research, aiming to offer valuable insights for future studies and contribute to addressing this serious health challenge.

drug therapy  /  metabolic dysfunction-associated steatotic liver disease  /  nonalcoholic fatty liver disease  /  pathogenesis  /  signaling pathway
Xin-yue WANG, Yan-xi LI, Yan ZHANG. Pathological mechanism and new progress in drug treatment of metabolic dysfunction-associated steatotic liver disease[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (23) : 3382 -3390 . DOI: 10.13699/j.cnki.1001-6821.2025.23.012
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Year 2025 volume 41 Issue 23
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Article Info
doi: 10.13699/j.cnki.1001-6821.2025.23.012
  • Receive Date：2025-11-17
  • Online Date：2026-08-05
  • Published：2025-12-17
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  • Received：2025-11-17
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Affiliations
    1.The First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    2.Department of Pharmacology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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