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To investigate the association between CAPN10 rs3792269 and SLC47A2 rs12943590 gene polymorphisms and the efficacy of metformin in type 2 diabetes mellitus (T2DM) patients receiving metformin monotherapy in Xinjiang, providing references for individualized drug therapy in local patients.
A total of 450 T2DM patients who had been regularly taking metformin monotherapy for ≥3 months from July 2024 to July 2025 in a tertiary hospital in Xinjiang were selected. Clinical data were collected and target locus genotypes were detected. Using glycated hemoglobin (HbA1c%) as the efficacy indicator, patients were divided into wild-type homozygous and mutant genotype groups. Propensity score matching (PSM) was employed to analyze the association between gene polymorphisms and efficacy, followed by post hoc power analysis.
The PSM analysis revealed that the CAPN10 rs3792269 A>G variant was an independent protective factor for good glycemic control (PSM-adjusted OR=0.478, 95%CI 0.266-0.862, P<0.05). In contrast, the SLC47A2 rs12943590 polymorphism showed no significant association with treatment efficacy. For the CAPN10 rs3792269 locus, the absolute difference in glycemic control rates between the two groups was 17.3%, with OR=2.10 and statistical power of approximately 90%. For the SLC47A2 rs12943590 locus, the absolute difference was 2.5%, with OR=0.91 and statistical power of only 7%.
This study clarifies that the CAPN10 rs3792269 A>G variant is significantly associated with improved efficacy of metformin in the Xinjiang population of China, while the SLC47A2 rs12943590 locus shows no association in this sample. The influence of genetic factors on metformin efficacy exhibits population heterogeneity. The sample size in this study provids sufficient power for detecting moderate to large effects, which may serve as a reference for individualized medication and blood glucose management in local patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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