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Cardiac fibrosis is a common pathological basis for a variety of cardiovascular diseases, and its core feature is cardiac fibroblast overactivation and extracellular matrix deposition, which ultimately leads to cardiac structural remodeling. Studies have shown that mitochondrial dysfunction is an important driver of the occurrence and development of cardiac fibrosis. Mitochondrial quality control is a set of precise dynamic regulatory systems in cells, involving mitochondrial dynamics, mitochondrial biogenesis and mitochondrial autophagy, which are responsible for maintaining mitochondrial homeostasis. Traditional Chinese medicine has the advantages of multiple pathways, multiple targets and small toxic side effects, and shows great potential in regulating mitochondrial quality control and treating cardiac fibrosis. Based on this, this paper systematically reviews the relationship between mitochondrial quality control and cardiac fibrosis and the mechanism of traditional Chinese medicine to regulate mitochondrial quality control in the treatment of cardiac fibrosis, aiming to provide a theoretical basis and new targets for the clinical treatment of cardiovascular diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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