Randomisation, controll and blinding are classic designs for drug clinical trials. This article introduced the classification and implementation of blinding, and the particularity of blinding in traditional Chinese medicine clinical trials. Then discussed some concerns about design and implementation of blinding in traditional Chinese medicine clinical trials, such as, should pay attention to the similarity evaluation of placebo, and should design the protocol and process based on the similarity of the placebo, and some problems about the blinding in the dose-finding trails and the packaging and label of investigational product.

new traditional Chinese medicine  /  clinical trial  /  blind  /  placebo  /  similarity evaluation  /  packaging and label