To collect the case reports of hypersensitivity reactions induced by etoposide and systematically summarize the characteristics, clinical manifestations, and treatment outcomes of hypersensitivity reactions, in order to provide corresponding reference for the safe use of etoposide.

The related case reports of hypersensitivity reactions induced by etoposide were retrieved and collected from databases such as China National Knowledge Infrastructure China Hospital Knowledge Base, Wanfang, VIP, Pubmed and Web of Science, and basic information such as patient gender, age, medication use, time of hypersensitivity reaction occurrence, and treatment outcomes was statistically analyzed as well.

A total of 27 case reports were finally included, involving 34 patients which included 21 males and 12 females and 1 patient whose gender was not mentioned. The average age of the patients was (45.83±15.50) years, with approximately 60% being over 40 years old. The majority of included cases were lung cancer patients, and the occurrence time of hypersensitivity reactions induced by etoposide was relatively short, with 18 patients experiencing hypersensitivity reactions within 1-10 minutes of medication, while only 3 patients had hypersensitivity reactions that occurred for more than 1 hour. Hypersensitivity reactions could affect many systems of the body, such as respiratory, circulatory, skin and its appendages. Common clinical manifestations of hypersensitivity reactions included difficulty breathing, chest tightness, papules, palpitations, hypotension, cyanosis; in addition, there were many serious cases such as anaphylactic shock. All cases showed improvement after treatment, and the patient did not experience any hypersensitivity reactions after receiving another infusion of etoposide, which had been pre treated with hormones or anti allergic drugs.

Hypersensitivity reactions induced by etoposide belong to immediate hypersensitivity reactions, characterized by short onset time, rapid progression, and good prognosis. In clinical practice, it is necessary to closely observe the status of patients during infusion of etoposide, strengthen medication monitoring, which can ensure the safety use of etoposide.