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Osteoarthritis, a degenerative bone disease commonly seen in the elderly, is particularly prevalent in weight-bearing joints such as the knee. Its etiology is multifactorial and characterized by pathological changes in the joint structure, including destruction and degeneration of articular cartilage, inflammatory response and formation of bone capillaries. Up to now, clinical treatment for osteoarthritis is mainly symptomatic treatment and pain relief, and there is no exact therapy that can reverse the pathological process of cartilage damage in osteoarthritis. In recent years, domestic and foreign scholars have found that mitochondria, as important organelles of chondrocytes, plays an important role in the process of cell metabolism, proliferation and apoptosis. It is also pointed out that mitochondrial autophagy imbalance is an important factor leading to cartilage damage in joints. Meanwhile, several basic experiments have shown that Chinese medicine exhibits the potential to protect cartilage by targeting the regulation of mitochondrial autophagy, thus showing positive results in the prevention and treatment of osteoarthritis. However, studies on this area have not been systematically elaborated. In view of this, the authors will systematically elaborate on the effects of mitochondrial autophagy on the development of osteoarthritis and the role of TCM in interfering with mitochondrial autophagy in the treatment of osteoarthritis, with the aim of providing new ideas and methods for the development of new medicines and therapeutic strategies for the treatment of osteoarthritis with TCM.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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