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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent airflow limitation. Its pathogenesis is complex and involves multiple pathological processes such as oxidative stress, inflammatory response and apoptosis. The mitogen-activated protein kinase (MAPK) signaling pathway plays a significant role in regulating cell growth, proliferation, differentiation and apoptosis. Modern research has confirmed that traditional Chinese medicine can exert therapeutic effects on COPD by intervening in the MAPK signaling pathway. This article reviews the regulatory mechanism of the MAPK signaling pathway on COPD and the intervention effect of traditional Chinese medicine on COPD in recent years, aiming to provide research basis for the development of new traditional Chinese medicine and the clinical application of traditional Chinese medicine in the treatment of COPD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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