To observe clinical curative effect and safety of propofol emulsion injection combined with sufentanil citrate injection for intravenous anesthesia in children undergoing laparoscopic repair of oblique inguinal hernia.

According to historical medication regimens, children undergoing laparoscopic repair of oblique inguinal hernia were divided into treatment group and control group. The control group was given intravenous pumping of propofol emulsion injection 4-10 mg·kg^-1·h^-1 and fentanyl citrate injection 3 μg·kg^-1·h^-1 for anesthesia maintenance, while treatment group was given intravenous pumping of propofol emulsion injection 4-10 mg·kg^-1·h^-1 and sufentanil citrate injection 0.3 μg·kg^-1·h^-1 for anesthesia maintenance. The hemodynamic indexes, emergence agitation, awakening quality, pain and postoperative analgesics use were compared between the two groups at different time points, and safety evaluation was performed.

According to electronic medical record, 427 children with oblique inguinal hernia were enrolled between June 2021 and 2024. Finally, 160 cases meeting the inclusion and exclusion criteria were included for grouping analysis, including 76 cases in control group and 84 cases in treatment group. Immediately after skin incision (T₁), heart rate (HR) in treatment group and control group were (92.67±5.06) and (97.53±4.97) time·min^-1, and mean arterial pressure (MAP) were (98.63±5.82) and (101.31±5.49) mmHg, respectively. At 5 min after the start of surgery (T₂), HR in treatment group and control group were (89.35±5.22) and (94.21±5.36) time·min^-1, and MAP were (96.97±5.13) and (99.29±4.75) mmHg, respectively. After the surgery (T₃), HR in treatment group and control group were (87.41±4.89) and (89.82±4.61) time·min^-1, and MAP were (93.82±5.67) and (96.71±5.03) mmHg, respectively. The incidences of emergence agitation in treatment group and control group were 3.57% (3 cases/84 cases) and 11.84% (9 cases/76 cases), awakening time were (8.21±1.76) and (10.45±2.59) min, recovery time of spontaneous respiration were (6.29±1.40) and (8.63±2.02) min, and extubation time were (12.43±2.51) and (15.87±3.08) min, respectively; immediately after awakening, scores of the face, legs, activity, cry, consolability behavioral tool (FLACC) in treatment group and control group were (2.08±0.59) and (2.43±0.65) points; at 1 h after awakening, FLACC scores were (1.75±0.47) and (2.12±0.61) points; at 6 h after awakening, FLACC scores were (1.42±0.41) and (1.73±0.49); at 12 h after awakening, FLACC scores were (1.28±0.36) and (1.56±0.43) points, and differences in the above indexes between the two groups were statistically significant (all P<0.05). The total dosages of postoperative analgesics in treatment group and control group were (33.51±3.21) and (41.98±3.94) mL, and compression frequency of analgesic pump was (1.55±0.42) and (2.89±0.75) times, the differences were statistically significant (all P<0.05). The adverse drug reactions were as follows: treatment group: nausea, hypotension, vomiting, dizziness; control group: nausea, hypotension, vomiting, dizziness. There was no significant difference in total incidence of adverse drug reactions between treatment group and control group [10.71% (9 cases/84 cases) vs. 9.21% (7 cases/76 cases), (P>0.05)].

Compared with propofol emulsion injection combined with fentanyl citrate injection, propofol emulsion injection combined with sufentanil citrate injection for intravenous anesthesia is beneficial to maintain hemodynamic stability, improve emergence agitation and awakening quality, relieve postoperative pain and reduce postoperative use of analgesics in children undergoing laparoscopic repair of oblique inguinal hernia, which has good safety.