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Research status on clinical application of targeted drugs in hepatocellular carcinoma
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Bo-zeng QIU1, 2, Jun-li LIN1, Jian-min GUO1, Song-qiang XIE2, Wei YANG1
Chinese Journal of Clinical Pharmacology | 2025, 41(11) : 1619 - 1623
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Chinese Journal of Clinical Pharmacology | 2025, 41(11): 1619-1623
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Research status on clinical application of targeted drugs in hepatocellular carcinoma
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Bo-zeng QIU1, 2, Jun-li LIN1, Jian-min GUO1, Song-qiang XIE2, Wei YANG1
Affiliations
  • 1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua Engineering Technology Research Center of Drugs Pharmacokinetics and Toxicokinetics, Guangzhou 510990, Guangdong Province, China
  • 2.School of Pharmacy, Henan University, Kaifeng 475000, Henan Province, China
Published: 2025-06-17 doi: 10.13699/j.cnki.1001-6821.2025.11.021
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Hepatocellular carcinoma (HCC) is the most common type of primary hepatocellular carcinoma, and advanced HCC is severe, difficult to treat, and has a poor prognosis. Since most patients have already lost the chance of surgery at the time of diagnosis, systemic drug therapy has become the main therapeutic tool. Currently, targeted therapeutic agents for advanced HCC are mainly divided into two categories: Tyrosine kinase inhibitors and vascular endothelial growth factor inhibitors. Approved tyrosine kinase inhibitors include sorafenib, lenvatinib, donafenib, regorafenib, cabozantinib and apatinib, etc. Vascular endothelial growth factor inhibitors include ramucirumab and bevacizumab. In recent years, the combination of targeted therapeutics and immune checkpoint inhibitors has effectively prolonged the overall survival of patients in several clinical trials, and this treatment model has become an important breakthrough in the current systemic treatment of advanced HCC. This article provides a brief introduction to the clinical application of targeted therapeutics for HCC.

targeted therapy drug  /  tyrosine kinase inhibitor  /  vascular endothelial growth factor inhibitor  /  hepatocellular carcinoma
Bo-zeng QIU, Jun-li LIN, Jian-min GUO, Song-qiang XIE, Wei YANG. Research status on clinical application of targeted drugs in hepatocellular carcinoma[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (11) : 1619 -1623 . DOI: 10.13699/j.cnki.1001-6821.2025.11.021
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doi: 10.13699/j.cnki.1001-6821.2025.11.021
  • Receive Date：2024-12-26
  • Online Date：2026-08-04
  • Published：2025-06-17
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  • Received：2024-12-26
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Affiliations
    1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua Engineering Technology Research Center of Drugs Pharmacokinetics and Toxicokinetics, Guangzhou 510990, Guangdong Province, China
    2.School of Pharmacy, Henan University, Kaifeng 475000, Henan Province, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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