Bone is the main target organ for malignant tumor metastasis, but there is still a lack of effective early diagnosis and treatment methods in clinical practice. Therefore, bone metastasis has become an important cause of death in patients with malignant tumors. Bone metastasis often causes a series of bone related events (SREs) such as pathological fractures, spinal cord compression, bone pain, and bone radiation therapy, seriously affecting the quality of life of patients. Based on previous researches and combined with domestic and foreign literatures. This review aims to elucidate the mechanism of bone microenvironment formation and escape, colonization, dormancy, reactivation, and proliferation in six stages. And summarize the latest research progress on the intervention of traditional Chinese medicine monomers and formulas in the process of tumor bone metastasis, clarify whether there is a synergistic effect of integrated traditional Chinese and Western medicine treatment on bone metastasis, in order to provide new ideas and medication basis for the in-depth study of the pathogenesis and drug treatment of tumor bone metastasis, aiming to further illustrate the advantages of multi-target treatment of traditional Chinese medicine and its important role in the treatment of tumor bone metastasis, and improve the efficacy of bone metastasis.