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To investigate the influencing factors of the dose-corrected concentration (C/D) of the active metabolite of oxcarbazepine (OXC) [10-hydroxycarbazepine (MHD)] and to provide the reference for the rational clinical use of this drug.
A total of 161 MHD blood concentrations were collected from the therapeutic drug monitoring (TDM) data of inpatients who received OXC treatment, as well as demographic information, comedications, diagnosis, and associated clinical chemistry results. Data analysis was carried out through the SPSS 27.0 software.
The effects of age, body mass index (BMI), comedications and diagnosis on MHD C/D values were statistically significant (all P<0.05). The C/D value of patients under 18 years old was higher than that of patients between 18 to 65 years old. The C/D value of female patients was higher than that of male patients in adults. The C/D value of the underweight group was higher than the normal, overweight and obese groups. The C/D value of patients combined with valproic acid was significantly lower than that of patients who didn’t. The C/D value of epilepsy patients was significantly lower than that of patients who weren’t diagnosed with this disease. Only 11 patients (8.20%) had blood sodium below the normal value range after medication, and there was no significant difference in blood sodium value, serum creatinine value, and glutamic-pyruvic transaminase value before and after treatment (all P>0.05). The results of multiple linear regression analysis showed that BMI had an effect on the C/D of MHD (P<0.05).
OXC has relatively good safety profile, and the effects of gender, age, BMI, comedications and diagnosis should be taken into consideration when OXC is prescribed.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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