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Research status of clinical and mechanistic on butylphthalide for Parkinson’s disease
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Miao YU1, 2, Chong-yang ZHANG1, 2, Xiao SUN2, Yun LUO2, Zun-peng SHU1, 3, Xiao-bo SUN2, Yan-fen CHEN1
Chinese Journal of Clinical Pharmacology | 2025, 41(8) : 1186 - 1190
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Chinese Journal of Clinical Pharmacology | 2025, 41(8): 1186-1190
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Research status of clinical and mechanistic on butylphthalide for Parkinson’s disease
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Miao YU1, 2, Chong-yang ZHANG1, 2, Xiao SUN2, Yun LUO2, Zun-peng SHU1, 3, Xiao-bo SUN2, Yan-fen CHEN1
Affiliations
  • 1.School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong Province, China
  • 2.Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine), Translational Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China
  • 3.Faculty of Arts and Sciences, Beijing Normal University, Zhuhai 519087, Guangdong Province, China
Published: 2025-04-28 doi: 10.13699/j.cnki.1001-6821.2025.08.024
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Parkinson’s disease (PD), a highly disabling neurodegenerative disorder, poses significant clinical challenges in both prevention and therapeutic intervention. Butylphthalide (NBP), a small-molecule compound derived from celery seeds, has garnered considerable attention due to its remarkable neuroprotective properties. This article systematically reviews recent studies, demonstrating that NBP not only ameliorates motor and non-motor symptoms in PD patients but also slows disease progression through modulation of neuroinflammation and mitochondrial function. By integrating clinical evidence with advances in molecular mechanism research, it provides a scientific foundation for in-depth investigation of NBP-based PD management and development of novel therapeutics.

butylphthalide  /  Parkinson’s disease  /  neuroinflammation  /  mitochondrial autophagy  /  ferroptosis
Miao YU, Chong-yang ZHANG, Xiao SUN, Yun LUO, Zun-peng SHU, Xiao-bo SUN, Yan-fen CHEN. Research status of clinical and mechanistic on butylphthalide for Parkinson’s disease[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (8) : 1186 -1190 . DOI: 10.13699/j.cnki.1001-6821.2025.08.024
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doi: 10.13699/j.cnki.1001-6821.2025.08.024
  • Receive Date：2024-12-28
  • Online Date：2026-08-04
  • Published：2025-04-28
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  • Received：2024-12-28
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Affiliations
    1.School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong Province, China
    2.Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine), Translational Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China
    3.Faculty of Arts and Sciences, Beijing Normal University, Zhuhai 519087, Guangdong Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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