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To establish a pharmacodynamic model of sodium-glucose transporter 2 inhibitors (SGLT-2i) in order to evaluate the efficacy characteristics of the drugs.
A model-based meta-analysis was used. By searching randomized controlled trials of SGLT-2i monotherapy in patients with type 2 diabetes (T2DM) in databases, the change in glycosylated hemoglobin (HbA1c) from baseline was used as the efficacy indicator. The pharmacodynamic models of SGLT-2i and placebo were constructed, and the covariates were screened to determine the factors affecting the drug’s efficacy.
A total of 39 studies were included, involving 96 trial groups, 8 534 participants, and 13 drugs (dapagliflozin, canagliflozin, empagliflozin, ipragliflozin, luseogliflozin, ertuglilfozin, enavogliflozin, henagliflozin, licogliflozin, sotagliflozin, bexagliflozin, janagliflozin and tofogliflozin). The time-effect relationships of the drug group and the placebo group were consistent with the Emax model, and fasting plasma glucose baseline had an effect on the pharmacodynamic parameters of SGLT-2i.
The final model can describe the pharmacodynamic characteristics of the drug and placebo groups, and there is a significant association between FPB baseline and drug efficacy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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