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Liver fibrosis is caused by various chronic injuries and metabolic disorders. Cirrhosis is the end stage of progressive liver fibrosis, which is estimated to affect 1% - 2% of the global population and cause more than 1 million deaths worldwide every year. Activation and maintenance of hepatic stellate cells (HSCs) are the main driving factors in liver fibrosis. At the same time, the process of trans-differentiation of HSCs involves reprogramming of energy metabolism, which is a key metabolic feature necessary to promote cell growth. Current studies found that Sirtuin protein family plays an important role in the progress of liver fibrosis, and further found that in the progress of liver fibrosis, especially after HSCs activation. Energy metabolism reprogramming involves various cells, including liver cells, HSCs, and immune cells. Targeting intracellular metabolism to limit fibrosis progression is currently a research hotspot. This article reviews the regulatory role of the Sirtuin protein family in energy metabolism in HSCs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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