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Protective effects of traditional Chinese medicine against oxidative stress in acute lung injury by modulating Keap1/Nrf2 signal pathway
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Guo-xiong HAO1, Xiao-jie JIN1, Qian XU1, Jia-yi WAN1, Xia-li LIANG1, Li-min ZHANG2, Zhi-ming ZHANG2
Chinese Journal of Clinical Pharmacology | 2025, 41(5) : 727 - 731
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Chinese Journal of Clinical Pharmacology | 2025, 41(5): 727-731
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Protective effects of traditional Chinese medicine against oxidative stress in acute lung injury by modulating Keap1/Nrf2 signal pathway
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Guo-xiong HAO1, Xiao-jie JIN1, Qian XU1, Jia-yi WAN1, Xia-li LIANG1, Li-min ZHANG2, Zhi-ming ZHANG2
Affiliations
  • 1.Key Laboratory of Molecular Medicine and Chinese Medicine Research on Prevention and Treatment of Major Diseases in Gansu Universities and Colleges, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Oncology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
Published: 2025-03-17 doi: 10.13699/j.cnki.1001-6821.2025.05.025
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Objective

Acute lung injury (ALI)/acute respiratory distress syndrome is a life-threatening acute diffuse inflammatory lung injury characterised by increased pulmonary vascular permeability, inflammatory cell infiltration, pulmonary oedema, diffuse alveolar damage and reduced respiratory output. Its pathogenesis is complex, and oxidative stress is a key mechanism leading to ALI exacerbated by alveolar epithelial cell dysfunction. The Kelch-like ECH associated protein 1 /nuclear factor -E2-related factor 2 (Keap1/Nrf2) signalling pathway is an important signalling pathway of traditional Chinese medicine in the treatment of ALI by regulating oxidative stress. This paper analyses and summarizes the relevant Chinese medicine formulas and active ingredients for the treatment of ALI, and finds that a large number of antioxidant active ingredients can regulate oxidative stress through the Keap1/Nrf2 signaling pathway and play a role in improving ALI, which also provides a basis for the prevention and treatment of ALI disease and further drug development.

Chinese medicine  /  acute lung injury  /  Kelch-like ECH associated protein 1 /nuclear factor -E2-related factor 2  /  oxidative stress
Guo-xiong HAO, Xiao-jie JIN, Qian XU, Jia-yi WAN, Xia-li LIANG, Li-min ZHANG, Zhi-ming ZHANG. Protective effects of traditional Chinese medicine against oxidative stress in acute lung injury by modulating Keap1/Nrf2 signal pathway[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (5) : 727 -731 . DOI: 10.13699/j.cnki.1001-6821.2025.05.025
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doi: 10.13699/j.cnki.1001-6821.2025.05.025
  • Receive Date：2024-09-18
  • Online Date：2026-08-04
  • Published：2025-03-17
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  • Received：2024-09-18
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Affiliations
    1.Key Laboratory of Molecular Medicine and Chinese Medicine Research on Prevention and Treatment of Major Diseases in Gansu Universities and Colleges, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Department of Oncology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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