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Airway remodeling is one of the pathological features of asthma and the direct cause of irreversible decline in lung function in asthma patients. Signal transducer and activator of transcription 3 (STAT3) can drive the differentiation of helper tlymphocyt (Th)2 and Th17 cells and the expression of cytokines. It plays a key regulatory role in airway remodeling processes such as metaplasia of bronchial epithelial goblet cells (GC), deposition of extracellular matrix (ECM), and epithelial mesenchymal transition (EMT) induced by proliferation of airway smooth muscle cells (ASMCs) in asthma. Therefore, the regulation of asthma airway remodeling related signal networks by STAT3 has become a new research hotspot in recent years. This article reviews the mechanism of STAT3 in regulating asthma airway remodeling from the perspective of signaling networks such as Janus kinase 2 (JAK2), nuclear factor kappa B (NF-κB), transforming growth factor-β1 (TGF-β1), interleukin-17 (IL-17), IL-6, providing a theoretical basis for the study of asthma airway remodeling mechanisms and the development of new drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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