PDF
Full
Outline
To analyze the correlations between topoisomerase Ⅱ alpha (TOP2A) and prognosis and immune infiltration in lung cancer.
The expression difference of TOP2A in lung cancer patients was examined by tumor immune estimation resource (TIMER) database. The prognostic value of TOP2A in lung cancer was evaluated using the Kaplan-Meier Plotter and PrognoScan databases. Additionally, the correlation between immune infiltration related gene marker sets and TOP2A expression was analyzed by TIMER database. The gene-gene and protein-protein interactions were determined using GeneMANIA and STRING for network construction, respectively. The possible regulatory network of TOP2A was explored by miRWalk and DIANA-LncBase v2 databases.
The expression of TOP2A in lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) was significantly upregulated and high expression of TOP2A was significantly associated with reduced overall survival, first progression survival, and post-progression survival in lung cancer patients. TOP2A expression was significantly correlated with the infiltration of immune cells in lung cancer, including monocytes, neutrophils, tumor-associated macrophages, helper T cells 1, regulatory T cells, and exhausted T cells. The majority of genes or proteins associated with TOP2A were involved in the regulation of gene transcription and cell cycle. An lncRNA (ENSG00000279978) was identified as being related to the progression of LUAD and LUSC.
TOP2A is an immune infiltration-related prognostic biomarker for lung cancer and may serve as a potential therapeutic target.
PDF
1
0
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
