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Research status of traditional Chinese medicine monomer components regulating TLR4/NF-κB signaling pathway in the treatment of liver cancer
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Zong-bo ZHANG1, Guo-jing MA2, Wei-wang TUO1, Jie HAI1, Hong-juan YANG1, Xu-dong TIAN3
Chinese Journal of Clinical Pharmacology | 2025, 41(3) : 422 - 427
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Chinese Journal of Clinical Pharmacology | 2025, 41(3): 422-427
• Review •
Research status of traditional Chinese medicine monomer components regulating TLR4/NF-κB signaling pathway in the treatment of liver cancer
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Zong-bo ZHANG1, Guo-jing MA2, Wei-wang TUO1, Jie HAI1, Hong-juan YANG1, Xu-dong TIAN3
Affiliations
  • 1.College of Integrative Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Gansu Provincial People’s Hospital, Gastroenterology Ward for Cadres, Lanzhou 730099, Gansu Province, China
  • 3.Spleen and Stomach Disease Diagnosis and Treatment Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
Published: 2025-02-17 doi: 10.13699/j.cnki.1001-6821.2025.03.025
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Toll-like receptor 4(TLR4)/ nuclear factor-κB (NF-κB) signaling pathway plays an important role in invasion, proliferation, migration, apoptosis and autophagy of hepatocellular carcinoma cells. Traditional Chinese medicine (TCM) monomers inhibit M2 macrophage polarization, epithelial-mesenchymal transformation (EMT), snail family transcriptional repressor 2 (SLUG) deubiquitination by ubiquitin-specific proteases (USP) and lipopolysaccharide (LPS) -induced cell damage by intervening TLR4/NF-κB signaling pathway. Serum inflammatory chemokine ligand 1(CXCL1) level and cyclooxygenase-2 (COX-2) protein level were significantly decreased and matrixmetalloprotease-9 (MMP-9) protein level was significantly decreased. The expression of MMP-9, decreased the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), and interfered with mitochondrial membrane potential (MMP), thereby inhibiting tumor cell invasion and migration, and promoting autophagy and apoptosis of hepatoma cells. The main purpose of this review is to update the latest TCM monomer components that exert anti-liver cancer effect through TLR4/NF-κB signaling, and to clarify the main mechanism of their action on liver cancer, and to provide ideas and methods for exploring more TCM with anti-liver cancer properties, so as to better promote the further development and utilization of TCM resources.

traditional Chinese medicine monomer  /  Toll-like receptor 4/nuclear factor-κB signaling pathway  /  liver cancer
Zong-bo ZHANG, Guo-jing MA, Wei-wang TUO, Jie HAI, Hong-juan YANG, Xu-dong TIAN. Research status of traditional Chinese medicine monomer components regulating TLR4/NF-κB signaling pathway in the treatment of liver cancer[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (3) : 422 -427 . DOI: 10.13699/j.cnki.1001-6821.2025.03.025
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Year 2025 volume 41 Issue 3
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doi: 10.13699/j.cnki.1001-6821.2025.03.025
  • Receive Date：2024-08-28
  • Online Date：2026-08-04
  • Published：2025-02-17
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  • Received：2024-08-28
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Affiliations
    1.College of Integrative Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
    2.Gansu Provincial People’s Hospital, Gastroenterology Ward for Cadres, Lanzhou 730099, Gansu Province, China
    3.Spleen and Stomach Disease Diagnosis and Treatment Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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