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To explore the effect of honey-processed Hedysari Radix on the metabolism of short-chain fatty acids (SCFAs) in the cecum of rats with spleen qi deficiency.
A total of 48 SPF male SD rats were randomly divided into blank group, model group, control group and experimental group, with 8 rats in each group. The blank group was fed normally, drank water and ate freely for 15 days, and the other groups used the three-factor composite modeling method of bitter cold diarrhea, overwork and hunger and satiety to construct a spleen qi deficiency model rats for 15 days. After the successful replication of the model, the rats in the control group were given 62.5 mg·kg-1 bifidobacterium Lactobacillus triple viable tablets suspension, the experimental group was given 12.6 g·kg-1 honey-processed Hedysari Radix decoction, and the blank group was given the same dose of distilled water, and the model group continued to model for 15 days. Gas chromatography-mass spectrometry (GC-MS) was used to determine the contents of SCFAs in the cecal contents of rats in each group.
The contents of acetic acid, isobutyric acid, butyric acid, isovaleric acid and caproic acid in the cecal contents of rats in the blank group were (3 706.24±401.84), (99.34±39.11), (2 567.95±529.44), (86.50±54.11) and (393.14±103.33) μg·g-1, respectively. Compared with the blank group, the contents of acetic acid, isobutyric acid, butyric acid, isovaleric acid and caproic acid in the cecum contents of spleen-qi deficiency rats in the model group were significantly reduced, which were (3 049.48±590.62), (67.27±12.99), (2 058.00±417.46), (43.10±11.12) and (27.98±14.40) μg·g-1, respectively (P<0.05, P<0.01). Compared with the model group, the contents of isovaleric acid and caproic acid in the cecum contents of rats in the experimental group were significantly increased, which were (90.59±26.03) and (60.05±19.89) μg·g-1, respectively (all P<0.01).
Honey-processed Hedysari Radix can play a role in strengthening the spleen and replenishing qi by improving the metabolism level of cecal contents, regulating the metabolism levels of SCFAs in cecal contents, protecting the intestinal mucosal barrier, and reducing intestinal inflammation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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