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The protective effects of treadmill exercise training on lung injury following spinal cord injury
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Xiao PAN1, Xianglian YANG1, Xianbin WANG1
Chinese Journal of Rehabilitation Medicine | 2026, 41(7) : 1028 - 1036
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Chinese Journal of Rehabilitation Medicine | 2026, 41(7): 1028-1036
The protective effects of treadmill exercise training on lung injury following spinal cord injury
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Xiao PAN1, Xianglian YANG1, Xianbin WANG1
Affiliations
  • The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001
Published: 2026-07-15 doi: 10.3969/j.issn.1001-1242.2026.07.003
Outline
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Objective:

To investigate the protective effects of treadmill exercise training on lung injury following spinal cord injury (SCI) and its potential underlying mechanisms.

Method:

A rat model of SCI was established and randomly divided into different intervention groups. The experimental group underwent treadmill exercise training, while the control group received no exercise intervention. Lung tissue was analyzed for the expression of inflammatory factors TNF-α and IL-6, the activity of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway, and the level of autophagy. These measures were used to assess the impact of exercise training on lung injury post-SCI.

Result:

Compared to the control group, treadmill exercise training significantly reduced the expression of inflammatory factors in the lungs post-SCI, activated the PI3K/AKT/mTOR signaling pathway, and promoted lung autophagy in lung tissue.

Conclusion:

Treadmill exercise training can mitigate lung injury after SCI by activating the PI3K/AKT/mTOR signaling pathway and promoting autophagy in lung tissue.

spinal cord injury  /  lung injury  /  treadmill exercise training  /  autophagy  /  PI3K/AKT/mTOR signaling pathway
Xiao PAN, Xianglian YANG, Xianbin WANG. The protective effects of treadmill exercise training on lung injury following spinal cord injury[J]. Chinese Journal of Rehabilitation Medicine, 2026 , 41 (7) : 1028 -1036 . DOI: 10.3969/j.issn.1001-1242.2026.07.003
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Year 2026 volume 41 Issue 7
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Article Info
doi: 10.3969/j.issn.1001-1242.2026.07.003
  • Receive Date：2024-06-25
  • Online Date：2026-07-23
  • Published：2026-07-15
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History
  • Received：2024-06-25
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    The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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