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Mechanisms of Maneb exposure-induced neurotoxicity and α-Synuclein aggregation
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Zhi-bing ZHANG1, Yan-yan FANG1, Kun PENG1, Xiang GAO1, Ze-hua LIU2, Fei LI1, Chao-yang LIU1, 3, *
China Environmental Science | 2026, 46(1) : 493 - 502
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China Environmental Science | 2026, 46(1): 493-502
• Environmental Toxicology and Environmental Health •
Mechanisms of Maneb exposure-induced neurotoxicity and α-Synuclein aggregation
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Zhi-bing ZHANG1, Yan-yan FANG1, Kun PENG1, Xiang GAO1, Ze-hua LIU2, Fei LI1, Chao-yang LIU1, 3, *
Affiliations
  • 1.Research Center for Environment and Health, Zhongnan University of Economics and Law, Wuhan 430073, China
  • 2.Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
  • 3.Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Published: 2026-01-20
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HEK293-α-syn cells and primary cortical neurons of wild-type mice were used as experimental models to deeply explore the environmental neurotoxicity and mechanism of Maneb exposure at different concentrations (0, 0.1, 1.0, 5.0mg/L). The results showed that Maneb exposure inhibited the activity of HEK293-α-syn cells in a dose-dependent manner and induced primary neuronal damage. The higher the Maneb exposure concentration, the more significant its toxic effect. In the 0.1mg/L experimental group, the apoptosis rate of neurons was close to 60%. In addition, Maneb exposure induced the aggregation ofα-syn in HEK293-α-syn cells and primary neurons, stimulated its abnormal phosphorylation at the S129 site, and upregulated the level of insoluble phosphorylated α-syn, further forming Lewy body (LB)-like aggregates, indicating that Maneb induces Parkinson's (PD)-like neurotoxicity.

Maneb  /  pesticide  /  α-synuclein  /  neurotoxicity  /  parkinson's disease
章智冰, 方艳艳, 彭锟, 高翔, 刘泽华, 李飞, 刘朝阳. 代森锰暴露诱导神经毒性和α-突触核蛋白聚集的机制. 中国环境科学, 2026 , 46 (1) : 493 -502 .
Zhi-bing ZHANG, Yan-yan FANG, Kun PENG, Xiang GAO, Ze-hua LIU, Fei LI, Chao-yang LIU. Mechanisms of Maneb exposure-induced neurotoxicity and α-Synuclein aggregation[J]. China Environmental Science, 2026 , 46 (1) : 493 -502 .
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Year 2026 volume 46 Issue 1
87
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  • Receive Date：2025-05-27
  • Online Date：2026-10-08
  • Published：2026-01-20
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  • Received：2025-05-27
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Affiliations
    1.Research Center for Environment and Health, Zhongnan University of Economics and Law, Wuhan 430073, China
    2.Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    3.Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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