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Systematic transcriptomic analysis reveals differential toxicity of three typical perfluoroalkyl substances
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Hui-dong WANG1, 2, Hao JIANG1, Jia-qi CAI1, Lu CHEN2, Li-jian DING1, An-yu NI3, Jin YAN4, Chun-ming DING1, Sheng-nan JIN1, *
China Environmental Science | 2025, 45(12) : 7008 - 7016
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China Environmental Science | 2025, 45(12): 7008-7016
• Environmental Toxicology and Environmental Health •
Systematic transcriptomic analysis reveals differential toxicity of three typical perfluoroalkyl substances
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Hui-dong WANG1, 2, Hao JIANG1, Jia-qi CAI1, Lu CHEN2, Li-jian DING1, An-yu NI3, Jin YAN4, Chun-ming DING1, Sheng-nan JIN1, *
Affiliations
  • 1.School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325000, China
  • 2.Centre for Disease Control and prevention, Nanhu District, Jiaxing 314000, China
  • 3.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200030, China
  • 4.School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China
Published: 2025-12-20
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Publicly available transcriptomic datasets from zebrafish exposed to three representative per- and polyfluoroalkyl substances (PFAS)—PFHxS, PFOA, and PFOS—were systematically integrated with behavioral data to elucidate comparative toxic potencies and neurotoxic mechanisms. Transcriptomic point-of-departure (tPOD) modeling identified PFOS as the most potent compound (120-h tPOD = 0.3241μmol/L), followed by PFHxS (0.3735μmol/L) and PFOA (0.4506μmol/L). Developmental stage-dependent increases in PFAS tolerance were observed. Behavioral meta-analysis revealed a characteristic biphasic "stimulation-inhibition" response pattern across all three PFAS, with enhanced locomotor activity at low concentrations and suppression at higher doses. Behavior-anchored transcriptomic profiling demonstrated that PFAS exposure broadly perturbed metabolic homeostasis and neural signaling pathways, with PFOS eliciting more pronounced disruptions in signal transduction and immune regulatory networks. Single-cell transcriptomic analysis further indicated that PFOS substantially altered neuronal subtype composition, suggesting that augmented excitatory synaptic activity may underlie the observed behavioral phenotypes.

per- and polyfluoroalkyl substances  /  transcriptomics  /  neurotoxicity  /  differential toxicity  /  zebrafish
王慧东, 姜浩, 蔡佳琪, 陈璐, 丁立健, 倪安煜, 闫瑾, 丁春明, 金胜男. 系统转录组分析揭示三种典型全氟化合物毒性差异. 中国环境科学, 2025 , 45 (12) : 7008 -7016 .
Hui-dong WANG, Hao JIANG, Jia-qi CAI, Lu CHEN, Li-jian DING, An-yu NI, Jin YAN, Chun-ming DING, Sheng-nan JIN. Systematic transcriptomic analysis reveals differential toxicity of three typical perfluoroalkyl substances[J]. China Environmental Science, 2025 , 45 (12) : 7008 -7016 .
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Year 2025 volume 45 Issue 12
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Article Info
  • Receive Date：2025-05-21
  • Online Date：2026-10-08
  • Published：2025-12-20
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  • Received：2025-05-21
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Affiliations
    1.School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325000, China
    2.Centre for Disease Control and prevention, Nanhu District, Jiaxing 314000, China
    3.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200030, China
    4.School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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