Full
Outline
To explore the mechanisms by which gut microbiota dysbiosis influences the health effects of microplastics (MPs), a systematic search was conducted across five English-language databases (PubMed, Embase, Scopus, Cochrane, and Web of Science) and three Chinese-language databases (CNKI, Wanfang Data, and China Biomedical Literature Database). Studies addressing gut microbiota-mediated health effects of MPs exposure in mice and rats were identified and reviewed. A total of 27 studies met the inclusion criteria. The animal models used were primarily C57BL/6 mice, aged between 4 and 12 weeks, mainly male. The MPs used were mainly polystyrene, with particle sizes ranging from 0.05~53μm. The primary exposure routes were oral gavage and free drinking water, with exposure durations ranging from 3 to 13 weeks. Microbial community analysis was primarily performed using 16S rRNA gene sequencing. The studies investigated gut microbiota on harm through the gut-organ axis (including the liver, brain, testes, bone marrow, and lungs) and the gut-function axis (encompassing immune and metabolic functions). Intestinal microflora mediates the damage of MPs to mice through various metabolic pathways (such as amino acids and lipids) and signaling pathways (including TLR 2-Myd 88-NF-κB and intestinal microflora -HIF 1α/PTBP 1). Further clinical studies are warranted to better elucidate the potential mechanisms by which gut microbiota modulates the health effects of MPs exposure in humans.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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