Multi-metal catalysts Mn-Cu-Co-Ce/TiO₂, Mn-Ce-Co/TiO₂, and Mn-Ce-Cu/TiO₂ were synthesized via the impregnation method. Among them, Mn-Cu-Co-Ce/TiO₂ was characterized before and after the reaction using BET, XPS, O₂-TPD, FT-IR, SEM-EDS, and XRD techniques. The catalytic performance of the catalysts for isopropanol degradation in a non-thermal plasma (NTP) synergistic system was investigated. The effects of initial concentration, gas flow rate, oxygen content, and catalyst water content on degradation efficiency were systematically analyzed. Organic byproducts generated during the degradation process were detected using gas chromatography-mass spectrometry (GC-MS), and the degradation mechanism under NTP conditions was explored. The results indicated that the NTP-assisted multi-metal catalyst system exhibited over 54% improvement in degradation efficiency compared to NTP alone, achieving a removal rate of 90.22%. CO₂ selectivity also increased by approximately 34%, reaching 63.97%. In the synergistic system, degradation efficiency was negatively correlated with initial concentration, gas flow rate, and catalyst water content, while it was positively correlated with voltage. Moreover, the formation of byproducts such as O₃was effectively suppressed. The degradation path of isopropyl alcohol may involve multiple aspects, including direct oxidation mineralization under the guidance of NTP, intermediate oxidation process, and deep redox reactions.