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In this study, zebrafish were used as a model organism to investigate the effects of combined exposure to polyamide microplastics（PA MPs）and triclosan（TCS）on lipid metabolism in larval zebrafish. The findings demonstrated that PA exhibited a strong adsorption capacity for TCS, with an adsorption rate reaching 74% at 168h. Exposure to PA and TCS from 6hpf to 120hpf resulted in pronounced morphological abnormalities in larval zebrafish, including pericardial edema, swim bladder closure, yolk sac edema, and spinal curvature, with a malformation rate of 13%. Moreover, combined exposure induced the accumulation of reactive oxygen species within the larvae, triggering oxidative stress responses. In the hepatic region, significant lipid accumulation was observed, accompanied by elevated levels of T-CHO and TG. These changes were further correlated with aberrant expression of genes involved in lipid metabolism, confirming that combined exposure to PA and TCS disrupted lipid metabolic processes in zebrafish. Mechanistic investigations revealed that combined exposure led to a reduction in mitochondrial membrane potential and decreased expression of ATP synthase genes, resulting in impaired energy supply and subsequent energy metabolism disruption. Notably, the presence of PA significantly amplified the disruptive effects of TCS on lipid and energy metabolism compared to exposure to either PA or TCS alone.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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